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Phenylarsine oxide : ウィキペディア英語版 | Phenylarsine oxide
Phenylarsine oxide (PAO) in an organometallic compound having the structure C6H5–As=O. It contains a phenyl group and an oxygen atom both boded to a central arsenic atom. The arsenic has a high affinity for the sulfur atom of thiols in organic compounds, in particular, forming stable complexes with vicinal cysteine residues in protein structures. This effect makes it useful for studying ligand–receptor binding This binding affinity also makes PAO useful for affinity chromatography by immobilizing it on a resin. It has a high selectivity for structures with vicinal cysteines rather than single cysteine residues or cystine (a disulfide-bridged pair of cysteine residues). ==References==
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